Imidazole → HCID 86633411、化合物

HRID 2387866ノート

反応式

HRID 2387866 の反応式
[NH2:1][CH2:2][C@@H:3]([OH:6])[CH2:4][CH3:5].[C:7]([Si:11](Cl)([CH3:13])[CH3:12])([CH3:10])([CH3:9])[CH3:8].N1C=CN=C1>CN(C=O)C>[Si:11]([O:6][C@@H:3]([CH2:4][CH3:5])[CH2:2][NH2:1])([C:7]([CH3:10])([CH3:9])[CH3:8])([CH3:13])[CH3:12]

参加物

5

反応物 3

HCID 795ImidazoleHCID 28928tert-Butyldimethylsilyl chlorideHCID 6995554(2S)-1-Amino-2-butanol

生成物 1

HCID 86633411HCID 86633411、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To the product from step (ii) (310 mg) in DMF (10 mL), tert-butylchlorodimethylsilane (734 mg) was added followed by imidazole (474 mg) and stirred at rt for 24 h. The mixture was washed with water and extracted with EtOAc, dried and the solvent removed to give the subtitle compound as a yellow oil, 610 mg.

後処理

  1. washThe mixture was washed with water
  2. extractionextracted with EtOAc
  3. customdried
  4. customthe solvent removed

出典と根拠

ORDレコード
ord-b3232efce3c34bd9b858e2e9481ecf73
出典データセット
uspto-grants-2012_09
特許番号
US08268990B2

反応ノート

読み込み中…