Hydrochloric Acid → HCID 68643985、化合物

HRID 2388670ノート

反応式

HRID 2388670 の反応式
[ClH:1].[OH:2][CH2:3][C@@H:4]1[CH2:13][CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]1C(OC(C)(C)C)=O>CO>[ClH:1].[NH:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[CH2:12][CH2:13][C@H:4]1[CH2:3][OH:2]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 57263166HCID 57263166、化合物

生成物 1

HCID 68643985HCID 68643985、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Hydrogen chloride in methanol (1.25 mol/l, 60 ml) was added to (S)-tert-butyl 2-(hydroxymethyl)-3,4-dihydroquinoline-1(2H)-carboxylate (3.98 g, 15.1 mmol) and the mixture was refluxed for 2 h. The solvent was removed in vacuo, the residue was taken up in ethanol (5 ml) and the mixture was cooled. Diethylether (200 ml) was added and the mixture was stirred in an ice bath for 30 min. The precipitate was filtered out with suction, washed with diethylether and dried in vacuo.

後処理

  1. temperaturethe mixture was refluxed for 2 h
  2. customThe solvent was removed in vacuo
  3. temperaturethe mixture was cooled
  4. additionDiethylether (200 ml) was added
  5. filtrationThe precipitate was filtered out with suction
  6. washwashed with diethylether
  7. customdried in vacuo

出典と根拠

ORDレコード
ord-05f1bd327e674993b3f39a04b1cb44bd
出典データセット
uspto-grants-2012_09
特許番号
US08268814B2

反応ノート

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