Hydrochloric Acid → 4,5,6,7-Tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride
反応式
[N:1]1[C:9]2[CH2:8][CH2:7][N:6](C(OCC)=O)[CH2:5][C:4]=2[S:3][C:2]=1[C:15]([O:17]CC)=[O:16].[ClH:20]>[OH-].[K+]>[ClH:20].[N:1]1[C:9]2[CH2:8][CH2:7][NH:6][CH2:5][C:4]=2[S:3][C:2]=1[C:15]([OH:17])=[O:16]参加物
4
反応条件
- 温度
- 0 °C
実験手順
Diethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate (1.76 mmol) in 3.5 N KOH solution (3 ml) was refluxed for 3 h (monitored by TLC). The reaction mixture was cooled to 0° C. and acidified with conc. HCl. The solid was collected by filtration and dried to yield the desired product. Yield: 60%.
後処理
- filtrationThe solid was collected by filtration
- customdried
出典と根拠
- ORDレコード
- ord-6296e09437c244a58b3c146934877e6e
- 出典データセット
- uspto-grants-2012_09
- 特許番号
- US08268814B2
反応ノート
読み込み中…