Acetyl chloride → Methyl 4-(piperidin-2-yl)butanoate hydrochloride

HRID 2388713ノート

反応式

HRID 2388713 の反応式
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][CH2:15][CH2:16][C:17]([O:19][CH3:20])=[O:18])=O)(C)(C)C.C([Cl:24])(=O)C>CO>[ClH:24].[NH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][CH2:15][CH2:16][C:17]([O:19][CH3:20])=[O:18]

参加物

4

反応物 2

HCID 6367Acetyl chlorideHCID 57904248Tert-butyl 2-(4-methoxy-4-oxobutyl)piperidine-1-carboxylate

生成物 1

HCID 66772062Methyl 4-(piperidin-2-yl)butanoate hydrochloride収率 100%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of tert-Butyl-2-(4-methoxy-4-oxobutyl)piperidine-1-carboxylate (3) (25.67 g, 89.9 mmol) in Methanol was added dropwise acetyl chloride. The reaction mixture was stirred for 5 h at room temperature. The completion of the reaction was controlled via Thin-layer chromatography. After completion the reaction mixture was evaporated in vacuum to give Methyl 4-(piperidin-2-yl)butanoate hydrochloride (4) (20.14 g, 100%)

後処理

  1. customAfter completion the reaction mixture was evaporated in vacuum

出典と根拠

ORDレコード
ord-326e635a29d846eab8e5aaec76825605
出典データセット
uspto-grants-2012_09
特許番号
US08268814B2

反応ノート

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