Ethanol → HCID 178482750、化合物

HRID 2388981ノート

反応式

HRID 2388981 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([C:9](=O)[CH2:10][C:11]2[CH:16]=[CH:15][C:14]([N:17]([CH3:19])[CH3:18])=[CH:13][CH:12]=2)[C:5](F)=[N:6][CH:7]=1.C(O)C.[NH2:24][NH2:25]>O>[Br:1][C:2]1[CH:3]=[C:4]2[C:9]([CH2:10][C:11]3[CH:16]=[CH:15][C:14]([N:17]([CH3:19])[CH3:18])=[CH:13][CH:12]=3)=[N:25][NH:24][C:5]2=[N:6][CH:7]=1

参加物

5

反応物 3

HCID 702EthanolHCID 9321HydrazineHCID 579757321-(5-Bromo-2-fluoro-3-pyridinyl)-2-[4-(dimethylamino)phenyl]ethanone

生成物 1

HCID 178482750HCID 178482750、化合物収率 57.2%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

1-(5-Bromo-2-fluoro-pyridin-3-yl)-2-(4-dimethylamino-phenyl)-ethanone (890 mg, 2.64 mmol), ethanol (100 ml), and anhydrous hydrazine (0.4 ml, 12.74 mmol) were combined and stirred for 18 hours at room temperature. The reaction was diluted with water and the precipitate filtered and dried to obtain 500 mg (57%) of [4-(5-bromo-1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-phenyl]-dimethyl-amine. MS m/z 331.1+333.1 (M+H+).

後処理

  1. filtrationthe precipitate filtered
  2. customdried

出典と根拠

ORDレコード
ord-f62fc04383c44312a0bf4f67a4b70136
出典データセット
uspto-grants-2012_09
特許番号
US08268994B2

反応ノート

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