Ethanol → HCID 178464723、化合物

関与物質

反応条件

反応手順

To a solution of (R)-4-Methyl-4-[6-(cis4-methyl-cyclohexyloxy)-naphthalen-2-yl]-oxazolidin-2-one (0.4420 g, 0.001302 mol) in ethanol (5.00 mL, 0.0856 mol) in a capped 40 mL vial was added 4.2 M Lithium hydroxide, monohydrate in water (2.8 mL). The mixture was heated overnight at 80° C. TLC analysis showed the reaction was complete. The mixture was concentrated to dryness under vacuum. Methylene chloride (5 mL) and water (5 mL) were added and the layers were separated (2×). The organic layer was concentrated under vacuum and purified by HPLC to give 0.0233 g of the title compound (6% yield). MS: m/z=297.29 [M-NH2]+. 1H NMR (400 MHz, MeOD) δ 0.98 (d, J=6.02 Hz, 3 H), 1.40-1.51 (m, 2 H), 1.51-1.60 (m, 3 H), 1.64-1.74 (m, 2 H), 1.79 (s, 3 H), 2.03-2.14 (m, 2 H), 3.83 (d, J=11.55 Hz, 1 H), 3.93 (d, J=11.55 Hz, 1 H), 4.69-4.77 (m, 1 H), 7.23 (dd, J=8.91, 2.38 Hz, 1 H), 7.27 (d, J=2.51 Hz, 1 H), 7.53 (dd, J=8.78, 2.01 Hz, 1 H), 7.79-7.89 (m, 3 H)

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