Dichloromethane → 4-(2-Cyano-1-benzofuran-5-yl)piperazin-1-ium chloride

HRID 2389270

反応式

HRID 2389270 の反応式
[C:1]([C:3]1[O:4][C:5]2[CH:11]=[CH:10][C:9]([N:12]3[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]3)=[CH:8][C:6]=2[CH:7]=1)#[N:2].C(Cl)[Cl:26]>CCOC(C)=O>[Cl-:26].[C:1]([C:3]1[O:4][C:5]2[CH:11]=[CH:10][C:9]([N:12]3[CH2:17][CH2:16][NH2+:15][CH2:14][CH2:13]3)=[CH:8][C:6]=2[CH:7]=1)#[N:2]

参加物

4

反応物 2

HCID 6344DichloromethaneHCID 67154775Tert-butyl 4-(2-cyano-1-benzofuran-5-yl)piperazine-1-carboxylate

生成物 1

HCID 671549194-(2-Cyano-1-benzofuran-5-yl)piperazin-1-ium chloride

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

The above piperazine (85.3 mg, 0.261 mmol) was dissolved in 5 mL of DCM and 5 mL of EtOAc, and cooled to 0° C. Hydrogen chloride gas was bubbled through the mixture for 30 seconds. The reaction stirred for 30 minutes, warming to ambient temperature. The slurry was concentrated to afford 4-(2-cyano-1-benzofuran-5-yl)piperazin-1-ium chloride.

後処理

  1. customHydrogen chloride gas was bubbled through the mixture for 30 seconds
  2. concentrationThe slurry was concentrated

出典と根拠

ORDレコード
ord-c928fe962c8f4c38b5c9417102e38a94
出典データセット
uspto-grants-2012_09
特許番号
US08273737B2

関連ノート

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