tert-Butyl {4-[(3-Chloro-benzo[b]thiophene-2-carbonyl)-(2-methoxy-5-pyridin-4-yl-benzyl)-amino]-cyclohexyl}-methyl-carbamate → 3-Chloro-benzo[b]thiophene-2-carboxylic acid (2-methoxy-5-pyridin-4-yl-benzyl)-(4-methylamino-cyclohexyl)-amide dihydrochloride

HRID 2389626ノート

反応式

HRID 2389626 の反応式
[Cl:1][C:2]1[C:3]2[CH:43]=[CH:42][CH:41]=[CH:40][C:4]=2[S:5][C:6]=1[C:7]([N:9]([CH2:25][C:26]1[CH:31]=[C:30]([C:32]2[CH:37]=[CH:36][N:35]=[CH:34][CH:33]=2)[CH:29]=[CH:28][C:27]=1[O:38][CH3:39])[CH:10]1[CH2:15][CH2:14][CH:13]([N:16](C)[C:17](=O)OC(C)(C)C)[CH2:12][CH2:11]1)=[O:8]>O>[ClH:1].[ClH:1].[CH3:39][O:38][C:27]1[CH:28]=[CH:29][C:30]([C:32]2[CH:33]=[CH:34][N:35]=[CH:36][CH:37]=2)=[CH:31][C:26]=1[CH2:25][N:9]([CH:10]1[CH2:15][CH2:14][CH:13]([NH:16][CH3:17])[CH2:12][CH2:11]1)[C:7]([C:6]1[S:5][C:4]2[CH:40]=[CH:41][CH:42]=[CH:43][C:3]=2[C:2]=1[Cl:1])=[O:8]

参加物

3

反応物 1

HCID 59683559tert-Butyl {4-[(3-Chloro-benzo[b]thiophene-2-carbonyl)-(2-methoxy-5-pyridin-4-yl-benzyl)-amino]-cyclohexyl}-methyl-carbamate

生成物 1

HCID 866189723-Chloro-benzo[b]thiophene-2-carboxylic acid (2-methoxy-5-pyridin-4-yl-benzyl)-(4-methylamino-cyclohexyl)-amide dihydrochloride

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

tert-Butyl carbamate 116 (75 mg, 0.12 mmol) is deprotected using Method E. On removal of the solvent in vacuo, the residue obtained is dissolved in water (5 mL) and washed with TBME (3×5 mL). Reduction of the aqueous phase in vacuo affords the title product.

後処理

  1. customOn removal of the solvent in vacuo
  2. customthe residue obtained
  3. washwashed with TBME (3×5 mL)

出典と根拠

ORDレコード
ord-83aca881af074234bb88c8fe91b335c4
出典データセット
uspto-grants-2012_09
特許番号
US08273747B2

反応ノート

読み込み中…