4-Bromobenzyl bromide → 1-Bromo-4-((methylsulfonyl)methyl)benzene

HRID 2389662ノート

反応式

HRID 2389662 の反応式
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[CH3:10][S:11]([O-:13])=[O:12].[Na+]>CN(C=O)C.O>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][S:11]([CH3:10])(=[O:13])=[O:12])=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 685274-Bromobenzyl bromideHCID 2733271Sodium methanesulfinate

生成物 1

HCID 27614151-Bromo-4-((methylsulfonyl)methyl)benzene

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

反応条件

温度
60 °C

実験手順

A stirred suspension of 4-bromobenzyl bromide (1.0 g, 4.0 mmol) and sodium methanesulfinate (2.04 g, 20 mmol) in DMF (10 mL) is heated 1 h at 60° C. The reaction mixture is then cooled to RT, diluted with water (200 mL) and extracted into EtOAc (3×25 mL). The combined EtOAc phases are washed with water (2×50 mL) and brine (25 mL) then dried (MgSO4) and reduced in vacuo to afford the title compound.

後処理

  1. temperatureThe reaction mixture is then cooled to RT
  2. extractionextracted into EtOAc (3×25 mL)
  3. washThe combined EtOAc phases are washed with water (2×50 mL) and brine (25 mL)
  4. dry with materialthen dried (MgSO4)

出典と根拠

ORDレコード
ord-8a5caa5386e04d3da1fb8d05878f75f4
出典データセット
uspto-grants-2012_09
特許番号
US08273747B2

反応ノート

読み込み中…