rac-tert-butyl N-methyl-N-[(1s,4s)-4-aminocyclohexyl]carbamate → HCID 59683625、化合物

HRID 2389678ノート

反応式

HRID 2389678 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[CH:10][C:11]([O:16][CH3:17])=[C:12]([CH:15]=2)[CH:13]=O)[CH:5]=[N:6][CH:7]=1.[C:18]([O:22][C:23](=[O:33])[N:24]([CH:26]1[CH2:31][CH2:30][CH:29]([NH2:32])[CH2:28][CH2:27]1)[CH3:25])([CH3:21])([CH3:20])[CH3:19]>>[C:18]([O:22][C:23](=[O:33])[N:24]([CH:26]1[CH2:27][CH2:28][CH:29]([NH:32][CH2:13][C:12]2[CH:15]=[C:8]([C:4]3[CH:5]=[N:6][CH:7]=[C:2]([F:1])[CH:3]=3)[CH:9]=[CH:10][C:11]=2[O:16][CH3:17])[CH2:30][CH2:31]1)[CH3:25])([CH3:21])([CH3:19])[CH3:20]

参加物

3

反応物 2

HCID 21938422rac-tert-butyl N-methyl-N-[(1s,4s)-4-aminocyclohexyl]carbamateHCID 549659235-(5-Fluoro-pyridin-3-yl)-2-methoxy-benzaldehyde

生成物 1

HCID 59683625HCID 59683625、化合物

実験手順

Following the synthetic protocol described in Method C′; {4-[5-(5-Fluoro-pyridin-3-yl)-2-methoxy-benzylamino]-cyclohexyl}-methyl-carbamic acid tert-butyl ester is prepared starting from 5-(5-Fluoro-pyridin-3-yl)-2-methoxy-benzaldehyde and (4-Amino-cyclohexyl)-methyl-carbamic acid tert-butyl ester. The desired product is isolated in 64%.

後処理

  1. custom{4-[5-(5-Fluoro-pyridin-3-yl)-2-methoxy-benzylamino]-cyclohexyl}-methyl-carbamic acid tert-butyl ester is prepared

出典と根拠

ORDレコード
ord-93f5fe0f972f44178e7cac5d80254140
出典データセット
uspto-grants-2012_09
特許番号
US08273747B2

反応ノート

読み込み中…