Potassium Hydroxide → HCID 178517803、化合物

HRID 2389741ノート

反応式

HRID 2389741 の反応式
[Cl:1][C:2]1[N:7]=[C:6](SC)[N:5]2[CH:10]=[CH:11][N:12]=[C:4]2[CH:3]=1.[OH-:13].[K+]>CO>[Cl:1][C:2]1[N:7]=[C:6]([OH:13])[N:5]2[CH:10]=[CH:11][N:12]=[C:4]2[CH:3]=1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 408159747-Chloro-5-(methylthio)imidazo[1,2-c]pyrimidine

生成物 1

HCID 178517803HCID 178517803、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 73.25 g (366.87 mmol) of 7-chloro-5-(methylthio)imidazo[1,2-c]pyrimidine are dissolved in 732 ml of methanol, and 1275 ml of a 2 molar aqueous potassium hydroxide solution are added. The mixture is heated under reflux for 3 h. After the reaction is complete, the methanol is removed in vacuo, the mixture is neutralized with half-concentrated hydrochloric acid, and the crystals which have separated out are filtered off with suction. They are washed with methanol and water and then dried under high vacuum. 40.0 g (64% of theory) of the product are obtained.

後処理

  1. temperatureThe mixture is heated
  2. temperatureunder reflux for 3 h
  3. customthe methanol is removed in vacuo
  4. customthe crystals which have separated out
  5. filtrationare filtered off with suction
  6. washThey are washed with methanol and water
  7. customdried under high vacuum
  8. custom40.0 g (64% of theory) of the product are obtained

出典と根拠

ORDレコード
ord-8e3efc5209f94e3d887ffb03dd1d1d58
出典データセット
uspto-grants-2012_09
特許番号
US08273752B2

反応ノート

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