Hydrochloric Acid → HCID 66911325、化合物
反応式
[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][NH:11]C(=O)OC(C)(C)C)[CH:5]=[CH:4][C:3]=1[C:19]#[N:20].[ClH:21]>O1CCOCC1>[ClH:21].[ClH:21].[NH2:1][C:2]1[C:3]([C:19]#[N:20])=[CH:4][CH:5]=[C:6]([NH:8][CH2:9][CH2:10][NH2:11])[N:7]=1参加物
4
実験手順
6.76 g (24.38 mmol) of tert-butyl {2-[(6-amino-5-cyanopyridin-2-yl)amino]ethyl}carbamate (Example 110A) are dissolved in 122 ml of 4N hydrogen chloride in dioxane and stirred for 30 min. The reaction mixture is concentrated to one half, and an equal portion of diethyl ether is added. The reaction mixture is stirred for 20 min, and the product is filtered off and washed with diethyl ether. 5.43 g (89% of theory) of the product are obtained as a solid.
後処理
- concentrationThe reaction mixture is concentrated to one half
- additionan equal portion of diethyl ether is added
- stirringThe reaction mixture is stirred for 20 min
- filtrationthe product is filtered off
- washwashed with diethyl ether
- custom5.43 g (89% of theory) of the product are obtained as a solid
出典と根拠
- ORDレコード
- ord-cf0ef50da7f343648cc34fd54a3c4f8f
- 出典データセット
- uspto-grants-2012_09
- 特許番号
- US08273752B2
反応ノート
読み込み中…