8,9-Dihydrofuro[3,2-c]pyrazolo[1,5-a]pyridin-1-ylacetonitrile → 2-(8,9-Dihydrofuro[3,2-c]pyrazolo[1,5-a]pyridin-1-yl)ethanamine
反応式
[C:1]1([CH2:13][C:14]#[N:15])[CH:2]=[N:3][N:4]2[CH:9]=[CH:8][C:7]3[O:10][CH2:11][CH2:12][C:6]=3[C:5]=12>N.CO.[Co]>[C:1]1([CH2:13][CH2:14][NH2:15])[CH:2]=[N:3][N:4]2[CH:9]=[CH:8][C:7]3[O:10][CH2:11][CH2:12][C:6]=3[C:5]=12参加物
4
実験手順
8,9-Dihydrofuro[3,2-c]pyrazolo[1,5-a]pyridin-1-ylacetonitrile (250 mg, 1.25 mmol) and Raney cobalt (2.5 g) were suspended in 2M ammonia/methanol solution (50 mL), and the suspension was stirred at room temperature for 12 hr under a hydrogen atmosphere. The catalyst was filtered through celite, and the filtrate was concentrated under reduced pressure to give the title compound (238 mg, yield 94%).
後処理
- filtrationThe catalyst was filtered through celite
- concentrationthe filtrate was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-575d0b644ce94160979ea230c77217b8
- 出典データセット
- uspto-grants-2012_09
- 特許番号
- US08273761B2
反応ノート
読み込み中…