関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Benzenamine, 3-ethynyl- | HCID 104682 | — |
| 反応物 | 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline | HCID 11289942 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Erlotinib Hydrochloride | HCID 176871 | 88.8% |
反応手順
5.0 g of 4-chloro-6,7-bis (2-methoxyethoxy) quinazoline was suspended in 75 ml water and 2.55 g of 3-aminophenyl acetylene was charged at 25-30° C. Further 1.0 ml 50% hydrochloric acid was added. The reaction mass was stirred at 25-30° C. for 2 hours. The solid obtained was filtered and washed with water. The product was dried at 40-45° C. to obtain 6.1 g of erlotinib hydrochloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08642758B2 |
|---|
| 出典データセット | uspto-grants-2014_02 |
|---|
| ORD ID | ord-aa922a47c9354357b4c91855f1dc64d8 |
|---|
| 出典メモ | uspto-grants-2014_02 |
|---|
