化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → Erlotinib Hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Benzenamine, 3-ethynyl- | HCID 104682 | — |
| 反応物 | 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline | HCID 11289942 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Erlotinib Hydrochloride | HCID 176871 | 84.4% |
反応手順
5.0 g of 4-chloro-6,7-bis(2-methoxyethoxy) quinazoline was suspended in 75 ml of water and 2.55 g of 3-aminophenyl acetylene was added at 25-30° C. followed by 1.0 ml of 50% hydrochloric acid. The reaction mass was heated at 35- 40° C. for 1 hour. The solid obtained was filtered and washed with water. The product was dried at 40-45° C. to obtain 5.8 g of erlotinib hydrochloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08642758B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-822db084f00c47e49c48714e4525ecda |
| 出典メモ | uspto-grants-2014_02 |