Triethylamine → HCID 59323470、化合物
反応式
[CH2:1]([C:3]1[CH:8]=[C:7]([CH2:9][OH:10])[CH:6]=[CH:5][N:4]=1)[CH3:2].C(N(CC)CC)C.[CH3:18][S:19](Cl)(=[O:21])=[O:20]>ClCCl>[CH2:1]([C:3]1[CH:8]=[C:7]([CH2:9][O:10][S:19]([CH3:18])(=[O:21])=[O:20])[CH:6]=[CH:5][N:4]=1)[CH3:2]参加物
5
実験手順
To a solution of 82 mg of 2-ethyl-4-hydroxymethylpyridine and 79 mg of triethylamine in dichloromethane (2 mL) was added 82 mg of methanesulfonyl chloride, followed by stirring at room temperature for 1 hour. It was purified by PLC (chloroform:methanol=10:1), dissolved in ethyl acetate, washed with an aqueous sodium bicarbonate solution and then with brine and then dried over anhydrous sodium sulfate, and the solvent was removed by evaporation to obtain 47 mg (yield 36%) of a title compound as a yellow oily substance.
後処理
- customIt was purified by PLC (chloroform:methanol=10:1)
- dissolutiondissolved in ethyl acetate
- washwashed with an aqueous sodium bicarbonate solution
- dry with materialwith brine and then dried over anhydrous sodium sulfate
- customthe solvent was removed by evaporation
出典と根拠
- ORDレコード
- ord-81ec05c99a6548638e25879b11a9efbb
- 出典データセット
- uspto-grants-2012_09
- 特許番号
- US08273766B2
反応ノート
読み込み中…