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HRID 2390125作成日：2026年10月26日

3-Bromo-4-fluorobenzyl Alcohol → Tert-butyl(4-chloro-2-{[2-fluoro-5-(hydroxymethyl)phenyl]ethynyl}phenoxy)acetate

https://huagongshe.com/reaction/2390125

反応式

関与物質

役割名称HCID仕込み量
反応物3-Bromo-4-fluorobenzyl AlcoholHCID 2773351—
反応物Tert-butyl(4-chloro-2-ethynylphenoxy)acetateHCID 56594381—
生成物Tert-butyl(4-chloro-2-{[2-fluoro-5-(hydroxymethyl)phenyl]ethynyl}phenoxy)acetateHCID 58521982—

反応手順

Following the general method as outlined in Intermediate 19, starting from tert-butyl(4-chloro-2-ethynylphenoxy)acetate (Intermediate 3) and 3-bromo-4-fluorobenzyl alcohol (Oakwood), the title compound was obtained as a dark brown sticky solid after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08273769B2
出典データセットuspto-grants-2012_09
ORD IDord-e04f653e86004338931c35289c9c0a8f
出典メモuspto-grants-2012_09