1-(2-Trimethylsilyl-1-ethynyl)-3-(propylsulfonyl)benzene → 1-Ethynyl-3-(propylsulfonyl)benzene

反応式

C(OC(=O)COC1C=CC(Cl)=CC=1C#C)(C)(C)C.C[Si](C)(C)[C:21]#[C:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([S:29]([CH2:32][CH2:33][CH3:34])(=[O:31])=[O:30])[CH:24]=1>>[C:22]([C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([S:29]([CH2:32][CH2:33][CH3:34])(=[O:30])=[O:31])[CH:24]=1)#[CH:21]

参加物

反応物 2

HCID 565942661-(2-Trimethylsilyl-1-ethynyl)-3-(propylsulfonyl)benzene2 回

HCID 56594381Tert-butyl(4-chloro-2-ethynylphenoxy)acetate

生成物 1

HCID 565942671-Ethynyl-3-(propylsulfonyl)benzene収率 70%

実験手順

Following the general method as outlined in Intermediate 3, starting from 1-(2-trimethylsilyl-1-ethynyl)-3-(propylsulfonyl)benzene (Intermediate 41), the title compound was obtained as a brown liquid in 70% yield after purification by column chromatography (silica) eluting with petroleum ether and ethyl acetate.

出典と根拠

ORDレコード: ord-380274e14d2f4bf48e1829b06270b25c
出典データセット: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08273769B2

反応ノート

読み込み中…

参加物