Trimethylsilylacetylene → Tert-butyl{4-cyano-2-[(trimethylsilyl)ethynyl]phenoxy}acetate

HRID 2390144ノート

反応式

HRID 2390144 の反応式
[C:1]([O:5][C:6](=[O:22])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12](Cl)=[CH:11][C:10]=1[C:16]#[C:17][Si:18]([CH3:21])([CH3:20])[CH3:19])([CH3:4])([CH3:3])[CH3:2].C(OC(=O)COC1C=CC([C:37]#[N:38])=CC=1Br)(C)(C)C.C[Si](C#C)(C)C>>[C:1]([O:5][C:6](=[O:22])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:37]#[N:38])=[CH:11][C:10]=1[C:16]#[C:17][Si:18]([CH3:21])([CH3:20])[CH3:19])([CH3:4])([CH3:3])[CH3:2]

参加物

4

反応物 3

HCID 66111TrimethylsilylacetyleneHCID 56594380Tert-butyl{4-chloro-2-[(trimethylsilyl)ethynyl]phenoxy}acetateHCID 58521856Tert-butyl 2-(2-bromo-4-cyanophenoxy)acetate2 回

生成物 1

HCID 58521908Tert-butyl{4-cyano-2-[(trimethylsilyl)ethynyl]phenoxy}acetate収率 87%

実験手順

Following the general method as outlined in Intermediate 2, starting from tert-butyl(2-bromo-4-cyanophenoxy)acetate (Intermediate 44) and (trimethylsilyl)acetylene (Aldrich), the title compound was obtained as a dark brown sticky solid in 87% yield.

出典と根拠

ORDレコード
ord-47256b9790624be4800c2434eaef6e3f
出典データセット
uspto-grants-2012_09
特許番号
US08273769B2

反応ノート

読み込み中…