Tert-butyl(4-chloro-2-ethynylphenoxy)acetate → Tert-butyl(4-cyano-2-ethynylphenoxy)acetate

反応式

C(OC(=O)COC1C=CC(Cl)=CC=1C#C)(C)(C)C.[C:19]([O:23][C:24](=[O:41])[CH2:25][O:26][C:27]1[CH:32]=[CH:31][C:30]([C:33]#[N:34])=[CH:29][C:28]=1[C:35]#[C:36][Si](C)(C)C)([CH3:22])([CH3:21])[CH3:20]>>[C:19]([O:23][C:24](=[O:41])[CH2:25][O:26][C:27]1[CH:32]=[CH:31][C:30]([C:33]#[N:34])=[CH:29][C:28]=1[C:35]#[CH:36])([CH3:22])([CH3:21])[CH3:20]

参加物

反応物 2

HCID 56594381Tert-butyl(4-chloro-2-ethynylphenoxy)acetate

HCID 58521908Tert-butyl{4-cyano-2-[(trimethylsilyl)ethynyl]phenoxy}acetate2 回

生成物 1

HCID 58522073Tert-butyl(4-cyano-2-ethynylphenoxy)acetate収率 72%

実験手順

Following the general method as outlined in Intermediate 3, starting from tert-butyl{4-cyano-2-[(trimethylsilyl)ethynyl]phenoxy}acetate (Intermediate 45), the title compound was obtained as an oil in 72% yield.

出典と根拠

ORDレコード: ord-5865ed61d9e3490ea8438efdd672659c
出典データセット: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08273769B2

反応ノート

読み込み中…