1-Fluoro-4-methanesulfonyl-2-nitrobenzene → 2-Fluoro-5-(methylsulfonyl)aniline

関与物質

反応手順

A mixture of 4-fluoro-3-nitrophenyl methyl sulfone (Acros; 1.00 g; 4.56 mmol) and PtO2 (100 mg) in MeOH (150 ml) was placed in a PARR reactor and treated with a pressure of 20 atm of hydrogen for 3 hours. The reaction mixture was filtered through Celite and the filtrate was concentrated to dryness affording the title compound (964 mg) as a dark green oil.

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