2-Bromo-5-methylsulfonylnitrobenzene → 1-Isopropenyl-4-(methylsulfonyl)-2-nitrobenzene
反応式
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8](/[CH:11]=[CH:12]/C)=[C:7]([N+:14]([O-:16])=[O:15])[CH:6]=1)(=[O:4])=[O:3].Br[C:18]1C=CC(S(C)(=O)=O)=CC=1[N+]([O-])=O.C(B1OC(C)(C)C(C)(C)O1)(C)=C>>[C:11]([C:8]1[CH:9]=[CH:10][C:5]([S:2]([CH3:1])(=[O:3])=[O:4])=[CH:6][C:7]=1[N+:14]([O-:16])=[O:15])([CH3:12])=[CH2:18]参加物
4
実験手順
Following the general method as outlined in Intermediate 59, starting from 2-bromo-5-methylsulfonylnitrobenzene and isopropenylboronic acid pinacol ester, the title compound was obtained as a brown oil in quantitative yield after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.
出典と根拠
- ORDレコード
- ord-10c7eb26203042649ac57ecb2fead673
- 出典データセット
- uspto-grants-2012_09
- 特許番号
- US08273769B2
反応ノート
読み込み中…