Water → 1-Methyl-2-nitro-4-(phenylsulfonyl)benzene

反応式

[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:4][C:3]=1[N+:15]([O-:17])=[O:16].[OH:18]OS([O-])=O.[K+].[OH2:24]>CO>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)(=[O:18])=[O:24])=[CH:4][C:3]=1[N+:15]([O-:17])=[O:16]

参加物

実験手順

A solution of 1-methyl-2-nitro-4-(phenylthio)benzene (Intermediate 111; 745 mg; 3.04 mmol) in MeOH (11 ml) and water (11 ml) was treated with Oxone® (5.60 g; 9.11 mmol) and the reaction mixture was stirred at RT for 6 hours. Water was added and the reaction mixture was extracted 2 times with DCM. The combined organic extracts were dried over MgSO4, filtered and concentrated to dryness affording the title compound as a beige solid (690 mg, 82%).