1-Bromo-4-(methylsulphonyl)benzene → 2-Methyl-5-(phenylsulfonyl)aniline
反応式
CS(C1C=CC(CCC)=C(C=1)N)(=O)=O.[CH3:15][C:16]1[CH:21]=[CH:20][C:19]([S:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)(=[O:24])=[O:23])=[CH:18][C:17]=1[N+:31]([O-])=O.CS(C1C=CC(Br)=CC=1)(=O)=O>CO.CCOC(C)=O>[CH3:15][C:16]1[CH:21]=[CH:20][C:19]([S:22]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)(=[O:24])=[O:23])=[CH:18][C:17]=1[NH2:31]参加物
6
実験手順
Following the general method as outlined in Intermediate 61 using MeOH and EtOAc as solvents, starting from 1-methyl-2-nitro-4-(phenylsulfonyl)benzene (Intermediate 112) and 4-bromophenyl methyl sulfone, the title compound was obtained as a beige solid in 94% yield.
出典と根拠
- ORDレコード
- ord-ef3929842697450580ce7764d3b6a8f4
- 出典データセット
- uspto-grants-2012_09
- 特許番号
- US08273769B2
反応ノート
読み込み中…