2,3-Epoxypropyl 4'-methoxyphenyl ether → Phenyl glycidyl ether

HRID 239021

反応式

HRID 239021 の反応式
[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][NH:8][C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]([CH2:20][CH3:21])[C:12]2=[O:22])=[O:10])[CH2:3][CH2:2]1.[CH3:23]O[C:25]1[CH:30]=[CH:29][C:28]([O:31][CH2:32][CH:33]2[O:35][CH2:34]2)=[CH:27][CH:26]=1>>[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][NH:8][C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]([CH:20]([CH3:23])[CH3:21])[C:12]2=[O:22])=[O:10])[CH2:3][CH2:2]1.[O:35]1[CH:33]([CH2:32][O:31][C:28]2[CH:27]=[CH:26][CH:25]=[CH:30][CH:29]=2)[CH2:34]1

参加物

4

反応物 2

HCID 166462,3-Epoxypropyl 4'-methoxyphenyl etherHCID 673783613-Ethyl-2-oxo-2,3-dihydro-benzimidazole-1-carboxylic acid (piperidin-4-ylmethyl)-amide

生成物 2

HCID 31217Phenyl glycidyl etherHCID 442491883-isopropyl-2-oxo-N-(piperidin-4-ylmethyl)-2,3-dihydro-1H-benzimidazole-1-carboxamide

実験手順

The procedure given in Example 104 was followed using 3-ethyl-2-oxo-2,3-dihydro-benzimidazole-1-carboxylic acid (piperidin-4-ylmethyl)-amide and glycidyl 4-methoxyphenyl ether as a reactant, instead of 3-isopropyl-2-oxo-2,3-dihydro-benzimidazole-1-carboxylic acid (piperidin-4-ylmethyl)-amide and 1,2-epoxy-3-phenoxypropane, to give the title compound.

出典と根拠

ORDレコード
ord-829d1f72d52f4f8a81395b93e97eb7cc
出典データセット
uspto-grants-2014_02
特許番号
US08642772B2

関連ノート

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