Morpholine → 4-(3-Bromobenzoyl)morpholine

反応式

Br[C:2]1[CH:15]=[CH:14][C:5]([C:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[O:7])=[CH:4][CH:3]=1.[Br:16]C1C=C(C=CC=1)C(Cl)=O.N1CCOCC1>>[Br:16][C:3]1[CH:4]=[C:5]([CH:14]=[CH:15][CH:2]=1)[C:6]([N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1)=[O:7]

参加物

反応物 3

HCID 8083Morpholine

HCID 74377Benzoyl chloride, 3-bromo-

HCID 5321484-(4-Bromobenzoyl)morpholine

生成物 1

HCID 5319934-(3-Bromobenzoyl)morpholine収率 71%

実験手順

Following the general method as outlined in Intermediate 174, starting from 3-bromobenzoyl chloride and morpholine, the title compound was obtained as a colorless sticky solid in 71% yield.

出典と根拠

ORDレコード: ord-95f8b6a8aa1c4556a2d4b9781ed8041d
出典データセット: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08273769B2

反応ノート

読み込み中…