3-Bromo-5-(methylsulfonyl)pyridine → HCID 56595046、化合物

反応式

C([O:5][C:6](=[O:18])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[C:16]#[CH:17])(C)(C)C.Br[C:20]1[CH:21]=[C:22]([S:26]([CH3:29])(=[O:28])=[O:27])[CH:23]=[N:24][CH:25]=1>>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:6]([OH:5])=[O:18])=[C:10]([C:16]#[C:17][C:20]2[CH:25]=[N:24][CH:23]=[C:22]([S:26]([CH3:29])(=[O:28])=[O:27])[CH:21]=2)[CH:11]=1

参加物

反応物 2

HCID 223919813-Bromo-5-(methylsulfonyl)pyridine

HCID 56594381Tert-butyl(4-chloro-2-ethynylphenoxy)acetate2 回

生成物 1

HCID 56595046HCID 56595046、化合物

実験手順

Following the general method as outlined in Example 35, starting from tert-butyl(4-chloro-2-ethynyl phenoxy)acetate (Intermediate 3) and 5-bromo-3-methylsulfonylpyridine (Combiblocks), the title compound was obtained as a white solid after purification by flash column chromatography (silica).

出典と根拠

ORDレコード: ord-e951ebb490a7403699e7c36254a3b2d8
出典データセット: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08273769B2

反応ノート

読み込み中…