Pyrazolo(1,5-a)pyridine-2-carboxylic acid → 4H,5H,6H,7H-pyrazolo(1,5-a)pyridine-2-carboxylic acid
反応式
[N:1]1[N:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]2=[CH:3][C:2]=1[C:10]([OH:12])=[O:11]>CO.[Rh]>[N:1]1[N:5]2[CH2:6][CH2:7][CH2:8][CH2:9][C:4]2=[CH:3][C:2]=1[C:10]([OH:12])=[O:11]参加物
4
実験手順
A solution of pyrazolo[1,5-a]pyridine-2-carboxylic acid (1 g, 6.17 mmol) in methanol (100 mL) was hydrogenated at 3½ bar over 5% rhodium on carbon (100 mg) overnight. The mixture was filtered through Celite and the pad was washed with methanol. The filtrates were evaporated to give the sub-title compound as a cream powder. Yield: 0.953 g
後処理
- filtrationThe mixture was filtered through Celite
- washthe pad was washed with methanol
- customThe filtrates were evaporated
出典と根拠
- ORDレコード
- ord-4a5abd52f2674f9e8429ad49c4f510f7
- 出典データセット
- uspto-grants-2012_09
- 特許番号
- US08273774B2
反応ノート
読み込み中…