関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | (2-Methoxypyridin-3-yl)boronic acid | HCID 2762709 | — |
| 反応物 | 5-Bromo-1-tert-butyl-2-methoxy-3-nitrobenzene | HCID 22930147 | — |
| 溶媒 | Dichloromethane methanol | HCID 21226129 | — |
| 生成物 | 3-(3-Tert-butyl-4-methoxy-5-nitrophenyl)-2-methoxypyridine | HCID 67070010 | 82% |
反応手順
step 1—A mixture of 5-bromo-1-tert-butyl-2-methoxy-3-nitrobenzene (0.48 g, 1.7 mmol; CASRN 474554-50-2), 37 (0.28 g, 1.8 mmol), Pd(PPh3)3 (0.19 g, 0.17 mmol) and Na2CO3 (0.53 g, 5.0 mmol) in DCM/MeOH (3:1, 8 mL) was subjected to microwave heating to 115° C. for 35 min. The reaction mixture was filtered and the filtrate concentrated. The crude residue was purified by SiO2 chromatography eluting with EtOAc/hexane to afford 0.44 g (82%) of 3-(3-tert-butyl-4-methoxy-5-nitrophenyl)-2-methoxypyridine (98) as a yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08273773B2 |
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| 出典データセット | uspto-grants-2012_09 |
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| ORD ID | ord-303d639c3a4c4b1ca35271abfa6ac019 |
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| 出典メモ | uspto-grants-2012_09 |
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