Methanesulfonyl chloride → N-(4-aminocyclohexyl)methanesulfonamide hydrochloride
反応式
[NH2:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH2:8])[CH2:4][CH2:3]1.[CH3:9][S:10]([Cl:13])(=[O:12])=[O:11]>C(Cl)Cl>[ClH:13].[NH2:1][CH:2]1[CH2:7][CH2:6][CH:5]([NH:8][S:10]([CH3:9])(=[O:12])=[O:11])[CH2:4][CH2:3]1参加物
4
実験手順
To trans 1,4-diaminocyclohexane (2.0 g, 17.5 mmol) in DCM at 0° C. (ice bath) was added methanesulfonyl chloride (1.63 mL, 21.0 mmol). The reaction was allowed to stir at RT for 1 h when a precipitate formed and was collected on a glass frit, rinsed with DCM, and dried to afford 2.56 g (64%) of 360.
後処理
- customformed
- customwas collected on a glass frit
- washrinsed with DCM
- customdried
出典と根拠
- ORDレコード
- ord-bac9290de9a24885a638d6a135a3e889
- 出典データセット
- uspto-grants-2012_09
- 特許番号
- US08273773B2
反応ノート
読み込み中…