Thiourea → 5,6,7,8-tetrahydro-4H-Thiazolo[4,5-d]azepin-2-amine hydrobromide

HRID 239096ノート

反応式

HRID 239096 の反応式
[NH2:1][C:2]([NH2:4])=[S:3].Br.[Br:6][CH:7]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9][C:8]1=O>C(O)C>[BrH:6].[S:3]1[C:7]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9][C:8]=2[N:1]=[C:2]1[NH2:4]

参加物

4

反応物 2

HCID 2723790ThioureaHCID 226207665-Bromoazepan-4-one hydrobromide

生成物 1

HCID 866860295,6,7,8-tetrahydro-4H-Thiazolo[4,5-d]azepin-2-amine hydrobromide収率 103.7%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

1.44 g thiourea was added to 4 g 5-bromo-azepan-4-one hydrobromide in 50 mL ethanol and stirred 3 h at 80° C. and over the weekend at RT. The precipitate was filtered and dried to yield 3.8 g of the product.

後処理

  1. filtrationThe precipitate was filtered
  2. customdried

出典と根拠

ORDレコード
ord-39df6a185c8547c2b9c3bdcbe6a8d702
出典データセット
uspto-grants-2014_02
特許番号
US08642774B2

反応ノート

読み込み中…