p-Toluenesulfonic acid monohydrate → 2-(1-Benzothiophen-5-yl)malonic acid
反応式
[S:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]([C:18]([O:20]C(C)(C)C)=[O:19])[C:11]([O:13]C(C)(C)C)=[O:12])=[CH:9][C:4]=2[CH:3]=[CH:2]1.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[S:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]([C:11]([OH:13])=[O:12])[C:18]([OH:20])=[O:19])=[CH:9][C:4]=2[CH:3]=[CH:2]1参加物
4
実験手順
To toluene (2.5 mL) solution of 0.25 g of di(tert-butyl) 2-(1-benzothiophen-5-yl)malonate was added 0.01 g of p-toluenesulfonic acid monohydrate, which was then refluxed for 1 hour. After cooling the reaction mixture, the precipitate was collected by filtration to provide 0.14 g of 2-(1-benzothiophen-5-yl)malonic acid as white solid form.
後処理
- temperaturewas then refluxed for 1 hour
- temperatureAfter cooling the reaction mixture
- filtrationthe precipitate was collected by filtration
出典と根拠
- ORDレコード
- ord-054bd898c26843d5af008bce44cc61f2
- 出典データセット
- uspto-grants-2012_09
- 特許番号
- US08273902B2
反応ノート
読み込み中…