4-Piperidinecarboxamide → 1-Benzylpiperidine-4-carboxamide
反応式
[CH2:1](Cl)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:9]1[CH2:14][CH2:13][CH:12]([C:15]([NH2:17])=[O:16])[CH2:11][CH2:10]1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH2:1]([N:9]1[CH2:14][CH2:13][CH:12]([C:15]([NH2:17])=[O:16])[CH2:11][CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
5
実験手順
10.2 mL benzylchloride was added to 10 g piperidine-4-carboxylic acid amide and 21.6 g potassiumcarbonate in 280 mL DMF at 5° C. The reaction was stirred over night at RT. The solvent was removed and the residue was dissolved in water and dichlormethane. The organic layer was separated and evaporated. The residue was purified by column chromatographie (silica gel, eluent: dichlormethane/methanol 95:5 to 90:10) to give 9.8 g of the desired product.
後処理
- customThe solvent was removed
- dissolutionthe residue was dissolved in water
- customThe organic layer was separated
- customevaporated
- customThe residue was purified by column chromatographie (silica gel, eluent: dichlormethane/methanol 95:5 to 90:10)
出典と根拠
- ORDレコード
- ord-d51ef4104a7f48138255f28aebcc2c3c
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08642774B2
反応ノート
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