Acetic Acid → 5-(4-Bromophenyl)-1,2-oxazole-4-carboxylic acid

HRID 2391108ノート

反応式

HRID 2391108 の反応式
C([O:3][C:4]([C:6]1[CH:7]=[N:8][O:9][C:10]=1[C:11]1[CH:16]=[CH:15][C:14]([Br:17])=[CH:13][CH:12]=1)=[O:5])C.C(O)(=O)C.O>Cl>[Br:17][C:14]1[CH:13]=[CH:12][C:11]([C:10]2[O:9][N:8]=[CH:7][C:6]=2[C:4]([OH:5])=[O:3])=[CH:16][CH:15]=1

参加物

5

反応物 3

HCID 176Acetic AcidHCID 962WaterHCID 22220993Ethyl 5-(4-bromophenyl)isoxazole-4-carboxylate

生成物 1

HCID 228317015-(4-Bromophenyl)-1,2-oxazole-4-carboxylic acid

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

5-(4-Bromo-phenyl)-isoxazole-4-carboxylic acid ethyl ester (0.500 g, 1.69 mmol) was dissolved in concentrated hydrochloric acid (2 mL), acetic acid (5 mL), and H2O (5 mL), and the reaction was stirred at 100° C. overnight. The mixture was partitioned between EtOAc and H2O, and the organic layer was separated, dried over MgSO4, filtered, and concentrated to give the title compound.

後処理

  1. customThe mixture was partitioned between EtOAc and H2O
  2. customthe organic layer was separated
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-bae1155603924c8ea866c158fa084018
出典データセット
uspto-grants-2012_09
特許番号
US08273780B2

反応ノート

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