Ammonia → 3-[(2-fluorobenzyl)oxy]-5-(1H-imidazo[4,5-c]pyridin-1-yl)thiophene-2-carboxamide

HRID 2391606ノート

反応式

HRID 2391606 の反応式
[F:1][C:2]1[CH:27]=[CH:26][CH:25]=[CH:24][C:3]=1[CH2:4][O:5][C:6]1[CH:10]=[C:9]([N:11]2[C:19]3[CH:18]=[CH:17][N:16]=[CH:15][C:14]=3[N:13]=[CH:12]2)[S:8][C:7]=1[C:20]([O:22]C)=O.[NH3:28]>CO>[F:1][C:2]1[CH:27]=[CH:26][CH:25]=[CH:24][C:3]=1[CH2:4][O:5][C:6]1[CH:10]=[C:9]([N:11]2[C:19]3[CH:18]=[CH:17][N:16]=[CH:15][C:14]=3[N:13]=[CH:12]2)[S:8][C:7]=1[C:20]([NH2:28])=[O:22]

参加物

4

反応物 2

HCID 222AmmoniaHCID 68765200methyl 3-[(2-fluorobenzyl)oxy]-5-(1H-imidazo[4,5-c]pyridin-1-yl)thiophene-2-carboxylate

生成物 1

HCID 687681693-[(2-fluorobenzyl)oxy]-5-(1H-imidazo[4,5-c]pyridin-1-yl)thiophene-2-carboxamide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
125 °C

実験手順

A mixture of 50 mg of methyl 3-[(2-fluorobenzyl)oxy]-5-(1H-imidazo[4,5-c]pyridin-1-yl)thiophene-2-carboxylate and 15 ml of a saturated solution of ammonia in methanol is stirred in a microwave vial at 125° C. for 4 h in the microwave cavity. The reaction mixture is concentrated to dryness, the resulting residue is recrystallized from 5 ml ethanol to yield the title compound.

後処理

  1. concentrationThe reaction mixture is concentrated to dryness
  2. customthe resulting residue is recrystallized from 5 ml ethanol

出典と根拠

ORDレコード
ord-64b4451fa0cb4688866044cc756106e6
出典データセット
uspto-grants-2012_09
特許番号
US08273890B2

反応ノート

読み込み中…