Water → 2-Bromo-5,6-dimethoxy-3-nitropyridine
反応式
Br[C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([N+:10]([O-:12])=[O:11])=[C:4]([Br:13])[N:3]=1.[CH3:14][O-:15].[Na+].O>CO>[Br:13][C:4]1[C:5]([N+:10]([O-:12])=[O:11])=[CH:6][C:7]([O:8][CH3:9])=[C:2]([O:15][CH3:14])[N:3]=1参加物
5
実験手順
20 g of 2,6-dibromo-3-methoxy-5-nitropyridine (example E3) were dissolved in 550 ml of anhydrous methanol at 30-40° C. 4.6 g sodium methoxide dissolved in 30 ml anhydrous methanol were added to this solution. The reaction mixture was stirred for one hour at room temperature, poured into 700 ml of water and stored in the refrigerator overnight. The precipitate was filtered, washed with ice cold water and dried under vacuum to yield the title compound.
後処理
- additionwere added to this solution
- customstored in the refrigerator overnight
- filtrationThe precipitate was filtered
- washwashed with ice cold water
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-b8291901f19049abb7a7146e154e55df
- 出典データセット
- uspto-grants-2012_09
- 特許番号
- US08273890B2
反応ノート
読み込み中…