2-Chloro-5-nitropyridin-4-amine → 4-Amino-2-methoxy-5-nitropyridine
反応式
Cl[C:2]1[CH:7]=[C:6]([NH2:8])[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][N:3]=1.[CH3:12][O-:13].[Na+]>CO>[CH3:12][O:13][C:2]1[CH:7]=[C:6]([NH2:8])[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][N:3]=1参加物
4
実験手順
To a suspension of 36.9 g of 2-chloro-5-nitropyridin-4-amine (example E6) in 500 ml methanol were added 250 ml of a freshly prepared solution of sodium methoxide in methanol (5.7 g sodium) and the reaction mixture was refluxed for 12 h. About 500 ml methanol were distilled off and 500 ml of water were added. The resulting precipitate was filtered, washed with ice water and dried under vacuum to the title compound.
後処理
- temperaturethe reaction mixture was refluxed for 12 h
- distillationAbout 500 ml methanol were distilled off
- addition500 ml of water were added
- filtrationThe resulting precipitate was filtered
- washwashed with ice water
- dry with materialdried under vacuum to the title compound
出典と根拠
- ORDレコード
- ord-79427f17aa874a13bd8704cebbe0f9f4
- 出典データセット
- uspto-grants-2012_09
- 特許番号
- US08273890B2
反応ノート
読み込み中…