化工社化工社 化学情報印刷レポート · 研究参考用
(Methoxycarbonylsulfamoyl)triethylammonium hydroxide → Benzyl 2-methyl-4,5,7,8-tetrahydrooxazolo[4,5-d]azepine-6-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (Methoxycarbonylsulfamoyl)triethylammonium hydroxide | HCID 11032497 | — |
| 反応物 | 4-Acetylamino-5-oxo-azepane-1-carboxylic acid benzyl ester | HCID 86686082 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Benzyl 2-methyl-4,5,7,8-tetrahydrooxazolo[4,5-d]azepine-6-carboxylate | HCID 86686083 | 814.9% |
反応手順
3 g 4-acetylamino-5-oxo-azepane-1-carboxylic acid benzyl ester in 100 mL tetrahydrofuran and 3.8 g (methoxycarbonylsulfamoyl)triethylammonium hydroxide were heated in a sealed tube at 75° C. for 1 h. The solvent was evaporated and the residue was purified by chromatographie on silica gel (ethyl acetate/hexane 1:2) to yield 23 g of the desired product. (M+H)+: 287
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08642774B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-70918a54ec1b45ceb69878ad78586d14 |
| 出典メモ | uspto-grants-2014_02 |