関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | Trimethylaluminum | HCID 16682925 | — |
| 反応物 | 5-(2,2,4-Trimethyl-piperazin-1-ylmethyl)-pyridin-2-ylamine | HCID 66914602 | — |
| 反応物 | 8-(2,6-Difluoro-3,5-dimethoxyphenyl)quinoxaline-5-carboxylic acid ethyl ester | HCID 86641145 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Dichloromethane methanol | HCID 21226129 | — |
| 生成物 | HCID 59292957 | HCID 59292957 | — |
反応手順
The title compound was prepared in analogy to the procedures described in Example 115 but using 8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid ethyl ester (Step 124.1), 5-(2,2,4-trimethyl-piperazin-1-ylmethyl)-pyridin-2-ylamine (Step 110.1), 1.5 equiv of trimethyl aluminum, stirring the reaction mixture for 6 h at 80° C. and pouring it onto a saturated aqueous solution of NaHCO3 and DCM. Title compound: ESI-MS: 563.1 [M+H]+; tR=3.55 min (System 1); TLC: Rf=0.08 (DCM/MeOH, 95:5).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08273882B2 |
|---|
| 出典データセット | uspto-grants-2012_09 |
|---|
| ORD ID | ord-c22f33710e854798a74732b77ac230cf |
|---|
| 出典メモ | uspto-grants-2012_09 |
|---|
