1-benzyl-2-nitro-1H-imidazole → 1-Benzyl-1H-imidazol-2-ylamine
反応式
[CH2:1]([N:8]1[CH:12]=[CH:11][N:10]=[C:9]1[N+:13]([O-])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Ni].CO>[CH2:1]([N:8]1[CH:12]=[CH:11][N:10]=[C:9]1[NH2:13])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
4
実験手順
A suspension of 1-benzyl-2-nitro-1H-imidazole (Step 160.2) (410 mg, 1.16 mmol) and Raney nickel (40 mg) in MeOH (10 mL) was stirred for 3 h at rt, under a hydrogen atmosphere. The reaction mixture was filtered through a pad of celite and concentrated to afford 345 mg of the title compound as a brown solid: ESI-MS: 173.9 [M+H]+; tR=2.02 min (System 1).
後処理
- filtrationThe reaction mixture was filtered through a pad of celite
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-99e7bb4646684a8c964faa63c6d9a567
- 出典データセット
- uspto-grants-2012_09
- 特許番号
- US08273882B2
反応ノート
読み込み中…