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2-Methoxyethylamine → 2,4-dichloro-N-(2-methoxyethyl)benzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methoxyethylamine | HCID 8018 | — |
| 反応物 | Benzenesulfonyl chloride, 2,4-dichloro- | HCID 204419 | — |
| 溶媒 | 1-Butanol | HCID 263 | — |
| 生成物 | 2,4-dichloro-N-(2-methoxyethyl)benzenesulfonamide | HCID 15943940 | — |
反応手順
2,4-Dichlorobenzenesulphonyl chloride (500 mg 2.1 mmol) and 2-methoxyethylamine (230 mg, 3.1 mmol) in n-butanol (10 ml) was heated at reflux for one hour. The volatiles were removed by evaporation and residue purified by chromatography eluting with hexane/ethyl acetate (50:50) to give the title compound. NMR: 3.04 (q, 21), 3.08 (s, 3H), 3.22 (t, 2H), 7.60 (dd, 31), 7.82 (d, 1H), 7.92 (d, 1H), 8.0 (s, 2H); m/z: 282 [M−H]−.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06855719B1 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-a5b0dfd666584ab9a114ab85faca21fa |
| 出典メモ | uspto-grants-2005_02 |