Propylamine → 2,4-dichloro-N-propylbenzenesulfonamide

HRID 23925

反応式

HRID 23925 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[S:9](Cl)(=[O:11])=[O:10].[CH2:13]([NH2:16])[CH2:14][CH3:15]>C(O)CCC>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[S:9](=[O:11])(=[O:10])[NH:16][CH2:13][CH2:14][CH3:15]

参加物

4

反応物 2

HCID 7852PropylamineHCID 204419Benzenesulfonyl chloride, 2,4-dichloro-

生成物 1

HCID 220249232,4-dichloro-N-propylbenzenesulfonamide

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

実験手順

2,4-Dichlorobenzenesulphonyl chloride (500 mg 2.1 mmol) and 1-propylamine (0.2 ml, 2.4 mmol) in n-butanol (10 ml) was heated at reflux for 48 hour. The volatiles were removed by evaporation and the residue triturated with ether and the product collected by filtration to give the title compound. NMR: 0.78 (t, 3H), 1.35 (q, 2H), 2.79 (t, 2H), 7.60 (dd, 1H), 7.84 (d, 1H), 7.92 (d, 2H)

後処理

  1. temperatureat reflux for 48 hour
  2. customThe volatiles were removed by evaporation
  3. customthe residue triturated with ether
  4. filtrationthe product collected by filtration

出典と根拠

ORDレコード
ord-37be21b4eed649eda844f890b04888da
出典データセット
uspto-grants-2005_02
特許番号
US06855719B1

関連ノート

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