Potassium Carbonate → 4'-(8-Hydroxyoctyloxy)biphenyl-4-carbonitrile

HRID 2392588ノート

反応式

HRID 2392588 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]#[N:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.Cl[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][OH:25].C(=O)([O-])[O-].[K+].[K+]>CC(CC)=O>[OH:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]#[N:15])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 900121-Octanol, 8-chloro-HCID 1406104'-Hydroxy-4-biphenylcarbonitrile

生成物 1

HCID 150484064'-(8-Hydroxyoctyloxy)biphenyl-4-carbonitrile収率 59.2%

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

実験手順

A solution of 5.0 g of 4'-hydroxybiphenyl-4-carbonitrile and 5.1 g of 8-chloro-1-octanol in 100 ml of ethyl methyl ketone was treated with 14.1 g of finely powdered potassium carbonate and the mixture was heated under slight reflux overnight. The suspension was suction filtered and the filtrate was concentrated in a vacuum. Chromatography of the residue on silica gel with hexane/ethyl acetate (vol. 1:1) gave 4.9 g of 4'-(8-hydroxyoctyloxy)biphenyl-4-carbonitrile.

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder slight reflux overnight
  3. filtrationsuction filtered
  4. concentrationthe filtrate was concentrated in a vacuum

出典と根拠

ORDレコード
ord-58fbab453721434b96adce0769141d78
出典データセット
uspto-grants-1998_09
特許番号
US05800733

反応ノート

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