Chloroacetone → HCID 21833778、化合物

HRID 2392643ノート

反応式

HRID 2392643 の反応式
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[S:7])=[CH:4][C:3]=1[CH3:11].Cl[CH2:13][C:14](=O)[CH3:15]>C(O)C>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]2[S:7][CH:13]=[C:14]([CH3:15])[N:8]=2)=[CH:4][C:3]=1[CH3:11]

参加物

4

反応物 2

HCID 6571Chloroacetone2 回HCID 21833829Benzenecarbothioamide, 4-bromo-3-methyl-

生成物 1

HCID 21833778HCID 21833778、化合物収率 98.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

4-Bromo-3-methylthiobenzamide (D38, 0.87 g, 0.0038 mole) was dissolved in ethanol (60 ml) and treated with chloroacetone (0.39 ml, 0.0049 mole). The reaction mixture was heated under reflux for 5 h, then more chloroacetone (0.39 ml, 0.0049 mole) was added and the mixture heated under reflux for a further 3 h. After cooling to room temperature, the solvent was removed in vacuo to leave the title compound as a pale oil (1.00 g, 98%).

後処理

  1. temperatureThe reaction mixture was heated
  2. temperatureunder reflux for 5 h
  3. temperaturethe mixture heated
  4. temperatureunder reflux for a further 3 h
  5. customthe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-552bc59c80c34212964b714e08f8ebce
出典データセット
uspto-grants-1998_09
特許番号
US05801170

反応ノート

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