Water → 1-(3-Methyl-4-nitrophenyl)-1,2,4-triazole
反応式
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([CH3:11])[CH:3]=1.[NH:12]1[CH:16]=[N:15][CH:14]=[N:13]1.C(=O)([O-])N.[K+].O>CS(C)=O>[CH3:11][C:4]1[CH:3]=[C:2]([N:12]2[CH:16]=[N:15][CH:14]=[N:13]2)[CH:7]=[CH:6][C:5]=1[N+:8]([O-:10])=[O:9]参加物
6
実験手順
A mixture of 4-fluoro-2-methylnitrobenzene (2 g), 1,2,4-triazole (0.9 g) and anhydrous potassium carbamate (1.78 g) was stirred and heated in dimethylsulphoxide (50 ml) at 90° C. for 24 hours. The reaction mixture was cooled, poured into water (200 ml) and extracted with ethyl acetate. The ethyl acetate layer was separated, dried (MgSO4) and evaporated to give an orange solid which was purified by chromatography on silica using pentane/ethyl acetate as eluant, (1.8 g, 69%).
後処理
- temperatureThe reaction mixture was cooled
- extractionextracted with ethyl acetate
- customThe ethyl acetate layer was separated
- dry with materialdried (MgSO4)
- customevaporated
- customto give an orange solid which
- customwas purified by chromatography on silica
出典と根拠
- ORDレコード
- ord-f9e6188675f84b12aff75eafdf396a33
- 出典データセット
- uspto-grants-1998_09
- 特許番号
- US05801170
反応ノート
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