Water → 1-(4-Nitrophenyl)-1H-1,2,4-triazole
反応式
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[NH:11]1[CH:15]=[N:14][CH:13]=[N:12]1.C(=O)([O-])[O-].[K+].[K+].O>CS(C)=O>[N:11]1([C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=2)[CH:15]=[N:14][CH:13]=[N:12]1参加物
6
反応条件
- 温度
- 90 °C
実験手順
4Fluoronitrobenzene (2 g, 0.014 mol), 1,2,4-triazole (1 g, 0.014 mol), potassium carbonate (1.96 g, 0.014 mol) were dissolved in DMSO (50 ml) and stirred at 90° C. for 24 h under dry conditions. The yellow suspension was poured into water (150 ml), extracted (EtOAc), dried (Na2SO4) and evaporated under reduced pressure to afford an orange solid which was purified by flash column chromatography on silica eluting with n-pentane/ethyl acetate (50-100%) to afford a white solid (2.57 g 97%).
後処理
- extractionextracted (EtOAc)
- dry with materialdried (Na2SO4)
- customevaporated under reduced pressure
- customto afford an orange solid which
- customwas purified by flash column chromatography on silica eluting with n-pentane/ethyl acetate (50-100%)
- customto afford a white solid (2.57 g 97%)
出典と根拠
- ORDレコード
- ord-a98078005de946f7bbb9ee7c31a04b54
- 出典データセット
- uspto-grants-1998_09
- 特許番号
- US05801170
反応ノート
読み込み中…