3-Bromoanisole → (1RS,2RS,4SR)-2-dimethylaminomethyl-4-isobutoxy-1-(3-methoxy-phenyl)-cyclohexanol hydrochloride

HRID 2392744ノート

反応式

HRID 2392744 の反応式
[ClH:1].[CH3:2][N:3]([CH2:5][CH:6]1[CH2:11][CH:10]([O:12][CH2:13][CH:14]([CH3:16])[CH3:15])[CH2:9][CH2:8][C:7]1=[O:17])[CH3:4].Br[C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH3:26])[CH:20]=1>>[ClH:1].[CH3:4][N:3]([CH2:5][CH:6]1[CH2:11][CH:10]([O:12][CH2:13][CH:14]([CH3:15])[CH3:16])[CH2:9][CH2:8][C:7]1([C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH3:26])[CH:20]=1)[OH:17])[CH3:2]

参加物

3

反応物 2

HCID 169713-BromoanisoleHCID 189805002-Dimethylaminomethyl-4-isobutoxy-cyclohexanone hydrochloride

生成物 1

HCID 18980492(1RS,2RS,4SR)-2-dimethylaminomethyl-4-isobutoxy-1-(3-methoxy-phenyl)-cyclohexanol hydrochloride収率 38%

実験手順

The base of compound (22) was reacted with 1-bromo-3-methoxy-benzene corresponding to the conditions described in Example 1. The base obtained was purified with 1:1 ethyl acetate/methanol via a silica gel column, and was taken up in ether. After adding trimethylchlorosilane/water, compound (20) was obtained in a yield of 38% theoretical.

後処理

  1. customThe base obtained
  2. customwas purified with 1:1 ethyl acetate/methanol via a silica gel column
  3. additionAfter adding trimethylchlorosilane/water

出典と根拠

ORDレコード
ord-91ca4fe8121d4a92b902973a702f38db
出典データセット
uspto-grants-1998_09
特許番号
US05801201

反応ノート

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