Triethylamine → 2-(4-Ethoxycarbonylpiperidino)-4-(3-chloro-4-methoxybenzyl)amino-6-cyanoquinazoline

HRID 2392895ノート

反応式

HRID 2392895 の反応式
[NH:1]1[CH2:11][CH2:10][CH:4]([C:5]([O:7][CH2:8][CH3:9])=[O:6])[CH2:3][CH2:2]1.C(N(CC)CC)C.Cl[C:20]1[N:29]=[C:28]([NH:30][CH2:31][C:32]2[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[C:34]([Cl:40])[CH:33]=2)[C:27]2[C:22](=[CH:23][CH:24]=[C:25]([C:41]#[N:42])[CH:26]=2)[N:21]=1>CC(O)C>[CH2:8]([O:7][C:5]([CH:4]1[CH2:3][CH2:2][N:1]([C:20]2[N:29]=[C:28]([NH:30][CH2:31][C:32]3[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[C:34]([Cl:40])[CH:33]=3)[C:27]3[C:22](=[CH:23][CH:24]=[C:25]([C:41]#[N:42])[CH:26]=3)[N:21]=2)[CH2:11][CH2:10]1)=[O:6])[CH3:9]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 70770Ethyl 4-piperidinecarboxylateHCID 211840042-Chloro-4-(3-chloro-4-methoxybenzyl)amino-6-cyanoquinazoline

生成物 1

HCID 211839262-(4-Ethoxycarbonylpiperidino)-4-(3-chloro-4-methoxybenzyl)amino-6-cyanoquinazoline収率 84.6%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

3.5 g of ethyl isonipecotate, 2.25 g of triethylamine and 30 ml of 2-propanol were added to 1 g of 2-chloro-4-(3-chloro-4-methoxybenzyl)amino-6-cyanoquinazoline. The obtained mixture was refluxed for 30 minutes and cooled to room temperature. The crystals thus precipitated were recovered by filtration and washed with water and ethanol successively to give 1.13 g of the title compound.

後処理

  1. temperatureThe obtained mixture was refluxed for 30 minutes
  2. customThe crystals thus precipitated
  3. filtrationwere recovered by filtration
  4. washwashed with water and ethanol successively

出典と根拠

ORDレコード
ord-7281e07bd7724b67a17a1fbf537c4ea2
出典データセット
uspto-grants-1998_09
特許番号
US05801180

反応ノート

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