Hydrochloric Acid → Methyl (R)-2-(4-hydroxyphenoxy)propionate
反応式
C([O:4][C:5]1[CH:17]=[CH:16][C:8]([O:9][C@H:10]([CH3:15])[C:11]([O:13][CH3:14])=[O:12])=[CH:7][CH:6]=1)(=O)C.Cl>CO>[OH:4][C:5]1[CH:6]=[CH:7][C:8]([O:9][C@H:10]([CH3:15])[C:11]([O:13][CH3:14])=[O:12])=[CH:16][CH:17]=1参加物
4
実験手順
A mixture of 45 g (189 mmol) of methyl (R)-2-(4-acetoxyphenoxy)propionate (enantiomeric excess 94-95%), 135 ml of methanol and 2.5 ml of methanol saturated with gaseous hydrogen chloride was refluxed for 5 h and subsequently concentrated. The crude product was purified by distillation at 140° C. under 0.1 mbar. Yield: 96% (94-95% enantiomeric excess).
後処理
- temperaturewas refluxed for 5 h
- concentrationsubsequently concentrated
- distillationThe crude product was purified by distillation at 140° C. under 0.1 mbar
出典と根拠
- ORDレコード
- ord-221fdf92b5cc45bd9fbc54f9021c4ee5
- 出典データセット
- uspto-grants-1998_09
- 特許番号
- US05801272
反応ノート
読み込み中…