4-(4-Methylphenylsulfonyl)phenylsulfonyl acetic acid → 4-(4-Ethylphenylsulfonyl)phenylsulfonyl acetic acid
反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]2[CH:16]=[CH:15][C:14]([S:17]([CH2:20][C:21]([OH:23])=[O:22])(=[O:19])=[O:18])=[CH:13][CH:12]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[CH2:24](C1C=CC(S(C2C=CC(CC(O)=S)=CC=2)(=O)=O)=CC=1)C>>[CH2:1]([C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]2[CH:16]=[CH:15][C:14]([S:17]([CH2:20][C:21]([OH:23])=[O:22])(=[O:19])=[O:18])=[CH:13][CH:12]=2)(=[O:9])=[O:10])=[CH:4][CH:3]=1)[CH3:24]参加物
3
実験手順
The intended 4-(4-ethylphenylsulfonyl)phenylsulfonyl acetic acid was prepared in the same manner as in the synthesis of 4-(4-methylphenylsulfonyl)phenylsulfonyl acetic acid of Example 6 except that 104 g of 4-(4-ethylphenylsulfonyl)phenylthio acetic acid was used in place of 100 g of 4-(4-methylphenylsulfonyl)phenylthio acetic acid. The yield was 97.1 g. NMR (heavy methanol): δ8.3-8.1 (m, 4H), 7.9 (d, 2H), 7.4 (d, 2H), 4.4 (s, 2H), 2.7 (q, 2H), 1.2 (t, 3H).
出典と根拠
- ORDレコード
- ord-18b5af8851614af6b29619286f6beb4b
- 出典データセット
- uspto-grants-1998_03